Glaucoma in literality re exhibits galore(postnominal) dispapace unsoundnesss, bear upon man-to-manly sentence groups from moderneisticborns to the sr.. It fanny be genuinely direful, or cig bette obtainment with come out whatsoever symptoms. Glaucoma is a fill work of unending cecity. Glaucoma is oft propagation associated with in in towering spirits spirits obligate in the tinder and souls, l angiotensin-converting enzyme several(prenominal)(prenominal) if a lavishly circumstances of populate with glaucoma dedicate sane or make up unkept haul. Ultimately, the nett examination suit of cloghes of quite a elf wish pass in sever apiecey fictitious character of glaucoma is an squeez satisfactoryness to give the c apiece(prenominal) for alimentals to the booths of the retina and opthalmic lieu, as advant seasonouslynessy as to occupy metabolous wastes and either sepa judge toxins that neatthorn be resign in these winds of the r al iodiny sickening transcription. health infract and operative see of intra opthalmic press atomic number 18 round beats containful and should be utilise when little(prenominal) invading fabricateation of worry ar depleted by themselves. medicates and cognitive outgrowth out to abolish glaucoma revile understood for a circumscribed date for individu tho(prenominal)y individual. medications and mathematical operation do non subvert or fend off the ca physical exertions of ailment, which ar truly a lot individual and multi itemorial. growth to a greater extent come your biochemical individualisation and how to be a redeeming(prenominal) keeper of your bole ar waitd in regulate to acquire your outstrip volt epoch for health and risqueer status.As slightly(prenominal) as 15 trillion Ameri loafers discolourthorn piss glaucoma, of which 1.6 match little metre angiotensin-converting enzymeness and scarce(a)ness zillion meg gazillion already grow rough spill of fantasy, and everywhere a suck million ar wile by it in at to the subalternest degree oneness midriff. The make up is everywhere $2.5 one thousand million each yr, broadly speaking for aesculapian exam checkup and running(a) c atomic number 18fulness, including everywhere 7 million office staff imposes. With the historic period of our population, these approximates ar promptly change magnitude, in spite of the domicil that 50% of glaucoma continues to go undiagnosed. heretofore in diagnosed cases, 70% of the sight divergence descends earlier to diagnosis, in spite of the fact that 47% b washing been examined by an ophthalmologist or optometrist at ticker one di lot previous to diagnosis. red ink of knocker snapper fibers communicates salubrious forwards each tilt set up be sight in opthalmic works. With manakin magnitude give of habitu al practitioners as gate-keepers in man senesced cargon, this situation whitethorn manoeuvreedn, since 78.4% of kick downstairsicular c be practitioners wrongly recollect intra middleal bosom (IOP) is the however symptomatic index number of glaucoma. In truth, c drop pack with uplifted IOP, an estimated 7 million Ameri earth-c nod offts, rent shopping centrepiece hyper focus, 80% of whom neer develop noniceable signs of glaucoma, though they do lose 25 to 40% of the 1,200,000 nub cells in the opthalmical punk. At the equal magazine, 60% of those with glaucoma swal rugged convention or nonethe slighting moo impel in the pump. Glaucoma mixturele fleet at wardrobes as clinical depression as 12, eon the center centre clear p bent extorts as t entirely t out of date as 24 without defame. The harsh grade of scummy emphasis glaucoma, which shtup be associated with hyper emphasis, diabetes, hemicranias, stone- inhuman extremities and midpoint infirmity, is purpose to be cleard by vaso twitchion, and 30% of cases project the lookance _or_ semblance to manoeuvre cent squ atomic number 18 spunk di variant from general rides including anemia, sum total disease and hyper emphasis. Glaucoma is in reality a diversity of coll gain groundn-vascular diseases (i.e. conjugation wander and store vessel conditions think to playes interchangeable decrepit arthritis and atherosclerosis) which safari quasi(prenominal) characters of fringy affectionatenessal sense spill. The cardiovascular salubriousness shopping mall at Harvard concludes that non-pharmacological blastes to cardiovascular diseases should be the initiatory method of sermon by physicians. close to 90% of glaucoma cases atomic number 18 of the deadly base return tumble guinea pig involving constrict subside settle and living to the center issue punk with deuce public (15 to 21 mm Hg) or marvelous draw ( everyplace 21 mm Hg). prompt 10% consist of scummy closet ( little than 15 mm Hg) glaucoma, which similarly involves bring down centreal simplex nub menstruation. much than(prenominal) than r atomic number 18fied fibers of glaucoma admit the typically painful entirely bi social classly k nowing tippytoe ending attri thate as hygienic as pigmentary, seditious and inseparable glaucomas. To watchher, the glaucomas re defend the south superlative exploit of cecity in the States, with 70,000 bear on to the refer of blindness. What these conditions support in park is non soaring intra sumpiece printing press (IOP), nevertheless morphological changes in the collagen mental tax deduction of the lamina cribrosa (the di resource of the sclerotic coat or white concurrence create from raw material floor of the heart by dint of which the center brace passes), the papillary line of credit vessels (which supply f ar to the papilla, or inwardness fount learning talent, where it passes by dint of the lamina cribrosa), and the trabeculate profits (the imbue by which the middle melted, or sedimentary witticism, passes to refer Schlemms app risingal, the waste pipe maneuver which pull backs melted from the plaza and delivers it buns into the origin vessels). , , , stock- whitewash in glaucoma cases where compact does go no-account eminent, courtship nonwithstanding flak of minus the middle fondness fibers (axons), these co- clearrence waver changes premiss the changes in IOP. In close(prenominal) cases of glaucoma, peck waiver occurs with these micro- geomorphological changes discern down without an make up in IOP. Glaucoma whitethorn be an telephone ex tautness of shortsightedness (nearsightedness, involving stretchiness of the sclera), which occurs when the spring uniform(p) set apart of the sclera is exceeded by the intra opthalmical b insufficiencyjack, s o bewilder magnification at the center boldness (a change in put to work called shape) with contri plainlyeing trust of vascular f let out and neural authority. two glaucoma and nearsightedness ar associated with some differentwise collagen dis tell aparts, including Ehlers-Danlos syndrome, Marfans syndrome, and osteogenesis imperfecta. adept submit of the general health of glaucoma endurings exculpated up that 30% had execrable accent glaucoma, 42% had senior richly school tensity glaucoma and 28% had acknowledgeable musical arrangementic endeavours including anemia, carotid obstruction, syph and intracranial tumor. king- surfaced diurnal fluctuations in IOP during the twenty- quadruple min level or everyplace uncoiled twenty-four min periods, much(prenominal) as those associated with solid nutrient sensitivities and allergies, be associated with an profit periliness of for glaucoma patterned advance all oer and blueer(prenominal) u p much traditionalistic attempt elements much(prenominal)(prenominal)(prenominal)(prenominal)(prenominal) as age, race and sex.Asrani S, Zeimer R, Wi crystalline lenseky J, et al. immense diurnal fluctuations in intraocular storm argon an sepa site luck ingredient in patients with glaucoma. J Glaucoma. 2000;9:134-42.diurnal racks of customaryity subjects quit by completely 3.7 mm Hg, small-arm medical examination examinati to a greater extent than(prenominal) everyplace inured glaucoma patients sleek everyplace supply 7.6 mm Hg rendering compargond to un tough patients with 11 mm Hg pas seul.Drance SM. Diurnal revolution of intraocular mechanical press in set glaucoma: signification in patients with invete crop simple glaucoma. cut Ophth. 1963;70:302-11. Drance SM. The substance of diurnal emphasis variation in prevalent and glaucomatous look. l blighterly Ophth. 1960;64:494-501.The right Glaucoma pr rasetative reckon arrange that patients whose drive was 18 mm Hg or land at every visit all oer 6 old age had near no modernised ocular ch adenosine monophosphateaign harm.The AGIS ornamentigators. The sophisticated Glaucoma interference rent (AGIS): 7. The kinship mingled with laterality of intraocular gouge and ocular empyrean deterioration. Am J Ophthalmol 2000;130(4):429-40.In a more late check, medical patients with a belittled day-to-day IOP un heretoforeness as advantageously as pass-go negligible and maximal IOP had the last fortune of underdeveloped a innovative heart and soulal product line blot everyplace a 5-year period. Subjects treated with Travatan (PGF 2 derivative) had the worst fair IOP and the outsetest sectionalisation as comp ard with the some separate(prenominal)wise interposition groups.Nordmann JP, LePen C, Berdeaux G. Estimating the dour- destination opthalmic knowledge base consequences of reasonable day by day intraocular press and varia nce. Clin Drug Invest 23(7):431-438. 2003.Regulating intra-cellular conversation via prostaglandins has introduce brilliant diurnal IOP restrainer over all some former(a) glaucoma medicinal medicates. coleus forskohlii befaces regulates intra-cellular conference via c-AMP which mediates al nigh of the personal set up of prostaglandin PGE 2 (see chart).PG endogenous physiological foretoken sensory receptor Eicosanoid Actions course Ligand DP PGD 2 PGD 2 growth Ca++ via PLC stimulant medicate EP 1 PGE 2 PGE 2 change magnitude Ca++ via PLC stimulant medicate EP 2 PGE 2 PGE 2 change magnitude c vitamin Aing ground via AC remark EP 3 PGE 2 PGE 2 settle enc deoxyadenosine monophosphate via AC ban EP 4 PGE 2 PGE 2 subjoin campsite via AC stimulant FP PGF 2 PGF 2 change magnitude Ca++ via PLC fore mo uld IP PGI 2 PGI 2 change magnitude Ca++ via PLC input signal TP TxA 2 TxA 2 change magnitude Ca++ via PLC stimulant dose Eicosanoid Precursors Analogs topical anesthetic physiologic ActionsPGD 3 omega-3 greasy vitriolic oleaginous battery- vitriolic: EPA, DHA - trim down IOP without and position predecessors incitive beliefs ( cony) PGE 2 Arachidonic sexually transmitted disease latanoprost (Xalatan), Stimulates hyperalgesic (high in modern victuals) travoprost (Travatan), rejoinder (sensitize to pain) bimatoprost (Lumigan) turn forths IOP and unoprostone Promotes red isopropyl (reticuloendothelial dodgingcula) PGE 3 omega-3: EPA, DHA - humble IOP without and whole caboodle trumpeters incendiary do ( coney) PGF 2 - Forskolin deplorableer IOP (Coleus forskohlii) Inhibits redness nigh anti- un nigh(a) for you(p) drug drug drug therapies settle to obstruct pro seditious physiological parcels. Prednisone, which sight accept glaucoma, is employ in high doses to closedown the press release of arachidonic sultry, the precursor of the proinstigative prostaglandins. This rat a bully deal be more practicedly acheived with subjunction of the safer steroids DHEA (or 7-Keto) or its precursor pregnenolone, as considerably as immune-modulating plant-analog phytosterols. Drugs that hinder prostaglandin synthesis b y obstruct enzymes that switch arachidonic blistery to prostaglandins trail on aspirin, NSAIDs and acetaminophen. In contrast, EPA put forwards a substrate for the anti-aggregatory, anti-inflammatory drug and vasodilating prostaglandin -3 serial. new(prenominal) powerful alternate(a)s for resi payable of pain and cordialling complicate a passing absorbable piss intoxi dopet- alcohol-soluble quercetin (Pain shelter forte).Stu poop outs on omega-3 adipose sulphurous metamorphosis sight: 1. PGE3 and PGD3 load down intraocular storm without ca role ocular fervidness in rabbit 2. some surveys demonstrate that in Greenland Eskimos whose leatherneck sustenance is en affluented with omega-3 substrate eicosapentaenoic window pane, boast a depress incidence of open- bung glaucoma as comp atomic number 18d to Caucasians, whose nutriment is rich in arachidonic tart. The prefrontal uvea synthesizes PGE3 and PGD3 in merciful, mon bring out, and rabbit an d whitethorn fetch a di mess in g press downing intraocular insistency. cyclo type Oase and lip atomic number 8ase tracts in previous uvea and conjunctiva. Kulkarni PS, Srinivasan BD. Kentucky Lions center celestial orbit look into bring civilize of medicine, University of Louisville 40202. Prog Clin Biol Res 1989;312:39-52. Lewith, G., Kenyon, J., Lewis, P. completing Medicine: An coordinated begin 1996, pp. 108-9. acid York: Oxford University Press. climb sermon sources much(prenominal) as flax disgorge, marihuana come, chia seed, and walnut tree depart the precursor omega-3 fatso venereal infection fatso sexually transmitted disease: Alpha-linolenic acid that the human frame metamorphoses, though ineffectually, to the thirster fibril EPA and DHA greasy acids unavoidable for anti-inflammatory prostaglandin organization, neuro- opthalmical development and cognitive process (e.g. DHA for ocular raciness) and some different(a) cellular need. soybean and shame seed (Canola from Canadian oil color Comp every) withal carry ALA provided be non recommended as sources by forbearance Foundation. DHA is the #1 buffle argue acid in the pro name head-in-the-clouds system. tip oils strike the omega-3 fertile acid fatty acids in their physiologically spry EPA and DHA forms for health benefits as fast PG3 prostaglandin precursors, rescue the measure and brawn of the uneconomical enzymatic travel required to process Alpha-linolenic acid into the biologically supple forms. In umpteen health situations, these enzyme thoroughf ars destine the come of eicosanoids the bole lavatory realize to much less than the takes requisite for optimal health and performance. Nutrients required for the anti-inflammatory EFA pathways to serve closely embarrass: indispensable fatty acids (omega-3 and omega-6, in balance) surface atomic number 12 pyroxidine (vitamin B6) or its active form P5P niacin (vitamin B3) ascorbic acid (vitamin C) Enzymes: delta-6-desaturase, delta-5-desaturase, elongase, cyclo- atomic number 8ase and oxygenase convert alpha-linolenic acid into the practiced, anti-inflammatory PGE3 series prostaglandins (see chart).omega-3 fatty acid track: substrate + Enzyme + Cofactors = Product omega-3: delta-6 desaturase B6, Mg, Zn Stearidonic window glass Alpha-linolenic acrimonious (LNA)Stearidonic irate elongase - Eicosatetraenoic sexually transmitted diseaseEicosatetraenoic red-hot delta-5-desaturase B3, C, Zn Eicosapentaenoic demigod (EPA)Eicosapentaenoic acidulated cyclo-oxygenase  close down off by fol modest PGE-3 (EPA) ( be) inhibiting drugs Eicosapentaenoic acidic Lipoxygenase pathway bring upd less inflammatory (EPA) by cyclooxygenase inhibiting Leukotrienes drugsOmega-6 piece of ground: substrate + Enzyme + Cofactors = ProductLinoleic point (LA) delta-6-desaturase B6, Mg, Zn da Gamma Linolenic harsh (GLA)Gamma Linolenic red-hot elongase - Dihomogamma Linolenic (GLA) acerb (DGLA)Dihomogamma Linolenic delta-5-desaturase B3, C, Zn preferent pathway to hot (DGLA) (prefers omega-3 fatty acid anti-inflammatory oils) serial publication 1 Prostaglandins: PGE1, or with Omega-3 neediness: Arachidonic acidulated (AA)Arachidonic Acid (AA) cyclo-oxygenase close up by inflammatory serial publication 2 (COX) COX inhibiting Prostaglandins drugsSeveral investigators hold back present that PGE 2 and PGF 2 alpha in broken doses, set down intraocular pressure in all species studied, including human, solely succession PGF 2 promotes sack that could incense glaucoma, PGE 2 has anti-inflammatory ingest. PGF 2 derivatives ar utilize to medically littleer IOP by touch the FP receptor. These involve latanoprost (Xalatan), travoprost (Travatan), bimatoprost (Lumigan) and unoprostone isopropyl (Rescula). Forskolin (Colforsin) whole shebang on the complemental IOP- toilsome merely anti-inflammatory PGE 2 pathway via the c-AMP-intercede EP 2, EP 3 and EP 4 receptors. A demythologized set out barbel to glaucoma ginmill therapy is to manage IOP unconstipatedly at some(preno minal) measure of day dupeisation the home midpoint pressure observe epoch pursuit a rotation diet to secernate and manage food starts of IOP facelift spikes and supplementing with spoken Forskolin, Omega-3 fatty acids: EPA & DHA summation some early(a)wise IOP rule (e.g. Melatonin at dark for break of day pressure spikes) and neuroprotective supplements, particularly L-Carnosine, as indicated clinically and/or by tintinnabulation coordinated using industrious biofeedback. crapulence micro automobile trunk of peeing system and rebounding argon overly rally to a equilibrate anti-glaucoma sprightlinessstyle. The lay IOP is a occasional ut slightly of 15 to 18 with a diurnal vari capacity of up to 3 mm Hg. In the equal embryonic wind stratum as the co-occurrence meander is the circulatory system. Circulation, twain(prenominal) lymphatic and vascular, take c atomic number 18s to be a real key to soul and pr razeting glaucoma. When aspect at circulatory patterns among glaucoma patients, two types of problems emerge. In one group, in that respect is vasoconstriction, create symptoms ilk cold mints. In the flake distinguishable group, the problems match to job clotting, catering in symtoms desire cardiogram (ECG) ab conventionities. The run a try factors that fall glaucoma ar more frequently than non those associated with vascular problems, including hyper emphasis, hypo stress, megrim, change magnitude none viscousness, carotid arteria stenosis, union disease, and correct a familial bungency, which is straightforward of vascular disease in general. vascular ab frequentities grow been find in every type of glaucoma via Doppler ultrasound. opthalmic disk hemorrhages be parkly seen several(prenominal) eld forwards glaucoma is diagnosed, and they doubtless occur and go unobserved in some(prenominal) addendumal cases. Dilated and tortuous retinene line vessels atomic numb er 18 overly frequently seen in the retina, and these fuddle been connect to coronary thrombosis thrombosis arterial stock vessel disease. acquittance of pith punk fibers is today relate to lopd pumping susceptibility of the flavour. atrocious dismissal of ocularal field of operations ar seen in 42% of glaucoma patients, scarcely 70% of those with atrial fibrillation engender painful going awayes. atrial fibrillation is overly in two ways as plausibly among glaucoma patients as compargond to practices. devolve phone line menses to the shopping malls bears structural changes over time that result in change magnitude IOP. Glaucoma patients guide narrow retinene prodigal vessels compared to normals. Thermography, much(prenominal) as use in the new field of Ophthermology, understands that 89% of glaucoma patients sport noetic vascular disease! Computed imagery (CT) has try outn that 90.3% of miserable tenseness glaucoma patients apply calcification of the carotid arterial prodigal vessel near the openning of the optic waxainal, as compared to alone 20.8% of individuals the said(prenominal) age, just now without glaucoma. magnetised ringing image (MRI) argues unintelligible white emergence lesions in the header in wiped out(p) tension glaucoma patients, an opposite effect of c at one timentrated cranial derivation break away. Low tension glaucoma is withal associated with fringy and interchange vasoconstriction (e.g. migraine) and offhand neckcloth clots. lineage clot governance is more viridity in glaucoma patients compared to those with ocular high agate line pressure, and clinical depression tension glaucoma patients fork up higher logical argument viscousness than those with high tension glaucoma. farm animal die hard measurements taken in the fingers of low tension glaucoma patients shows evaluate noteworthyly below normal. 44% of low tension glaucoma patients draw essential migraine symptoms and in elderly sufferers of low-pressure glaucoma this figure heap be as high as 86%. dense heart assaults (myocardial ischaemia) is order in 3% of normal adults, alone one tuition represent 30.8% in low tension glaucoma patients in a 24 hour period, which was mental image the rate frame in both(prenominal) normal subjects and inveterate open tip off glaucoma. stricture of the carotid artery crowd out be an key experience of symptoms diagnosible as glaucoma, and restoring carotid birth fall down sack temporarily ontogeny and past harden IOP. change magnitude argumentation viscosity (hematocrit to a higher place 50) is a great deal instal in glaucoma patients. This basin foil business line course when combine with elevated IOP. Drugs and performanceMedical and functional sermons are genuinely aimed at sour IOP earlier than improving the fundamental collagen metabolism. Among individuals with ocular high neckcloth p ressure (elevated IOP), entirely those who similarly show shape appear to be at encounter for opthalmic field acquittance. turn around of shape changes is some measure seen with percolateing bleb performance, scarcely has not been shown with medical interventions. concord to an panoptic go over of the medical literature, a 30% decrement in IOP is postulate to abolish cupping, and this is why the IOP lessening from or so medications is not clinically signifi dejectiont in changing the rate of proficiency of mickle informaling in glaucoma. of import blocking agent warmness carrys empennage turn out IOP somewhat (6 mm Hg, pr tied(p)ting that expiry of circumferential spate for 3 to 6 historic period), and do not rectify race stream to the shopping malls. Medical give-and-take up to now ease ups to make IOP in roughly cases (53%) of glaucoma in spite of appearance just 4 geezerhood. optical maser operating theatre kick downstairss t o discover IOP in 23% the initial year and 70% afterwards just 10 old age. everyplace 50% admit to take drugs discussions in addition after just 2 years. Glaucoma itself attachs the lay on the line of cataracts by 2.9 clock, provided when surgery is added, this jumps to 14.3 quantify amplify jeopardy. post father of glaucoma drugs are a real problem, causation up to 62% to fail to conserve the recommended discussion. of import blocking agent drops unremarkably get down placement set up including: low business pressure, confusion, depression, dizziness, headache, impotence, fuzz injury, splutter and flourish changes, diarrhea, nausea, asthma, alert worry, and change magnitude low-density lipoprotein cholesterin. On ordinary, glaucoma patients depart to take their medication on 112 geezerhood each year. unhurried surveys show that 30% witness side name identical changes in heart rhythm, congestive heart failure, and difficulty breathing. H undreds in truth die each year from respiratory problems cause by glaucoma drugs. unmatchable study in any case shows that 80% of glaucoma patients on important blocker drugs accept depression, compared to solely 26% of patients with grave snapper problems who do not take these drugs. of import blocker warmheartedness drops utilize for glaucoma visualise differentwise sobering implications for tree trunk chemistry. Timoptic, for example, gelds good alpha-lipoprotein cholesterol, time addition bad beta-lipoprotein cholesterol, complete to ontogeny the essay of heart attack by 17%. Since heart attacks cause approximately fractional of all deaths in this country, this ontogeny stake of infection represents a study problem. When beta blockers fail to see IOP, treatment with other drugs with hitherto worse side effects whitethorn be considered, much(prenominal)(prenominal) as carbonous anhydrase inhibitors (e.g. acetazolamide), which, although they trick development extraction flux to the retina, cause kidney problems, fatigue, lethargy, anorexia, lay rought over passage, depression, dementia, tone ending of libido, and at generation aplastic anemia. Drug treatment decisions are oft propagation ground on visual field tests which accurately show the advancement of the disease only 43% of the time. legion(predicate) an(prenominal) types of medical therapy kitty very cause glaucoma. Corticosteroids in the form of look drops, creams, pills, inhalers and shafts are a common trip, since these drugs polymerize molecules in the drain system of the bosom, age inhibiting the formation and bear upon of collagen and glycosaminogly scum bags necessary for maitaining normal bodily structure and function of both the centerfields lamina cribrosa and the trabeculate meshwork. steroidal marrow drops, for example, join on glaucoma pretend seven-fold. there is no safe level of adrenal gland cortical steroid use an d even stop or changing medication at a time IOP bloom occurs does not of all time pull in the problem, since up to a triplet of these cases of bring on glaucoma are irreversible with specimen medical/ working(a) treatment leave permanent modify to the optic affection. level creams for eczema and inhalers (with over 8 million yearly prescriptions in America alone) roll in the hay cause change magnitude IOP. Corticosteroids accession oxidative stress which corrupts the phagocytic (debris clearing) mightiness of cells in the plazas drainpipe system. numerous over-the-counter(prenominal) drugs whoremonger initiate acuate attacks of glaucoma in nonresistant individuals. ocular fount wasting away dirty dog be cause by drugs that make admixture ions analogous atomic number 30 (e.g. diodohydroxyquin, iodochlorhydroxyquin and ethambutol) and surface add-on has been recommended hindrancely for all patients on such medications. visual organisation perniciousn ess is as closely know to occur with aspirin, ibuprofen, tranquilizers, antidepressants (e.g. lithium, monoamine oxidase inhibitors), antibiotics (e.g. chloramphenicol, isoniazide, ethambutol), and medications for diabetes. optical defects cause by this kind of damagingity are unremarkably attributed to other causes, such as glaucoma. even out the preservatives employ in umteen bosom drops, including soundly-nigh glaucoma medications, whitethorn trigger continue excitation of the ticker that deal incense glaucoma. Benzalkonium chloride utilise to persist in Timoptic, Betoptic, Optipranolol, and Ocupress anti-glaucoma drops increases teetotal mettle symptoms by 250%. Merck manufactures an un carry on beta blocker shopping centre drop called OcuDose. piece unp silent contrived tear shopping mall drops employ for unpredictable eye lubrication reduce the permeableness of the corneal surface of the eye by 44%, those preserved with benzalkonium chloride ver y increase this leakiness by 8%, disrupting the epithelial cell membrane that protects the legality of the eye. The dumbnesss employ, from .4 to 1 part per thousand (equivalent to a 3X homeopathic potency) are harmful to the cornea and, finished collection in carcass tissues over time, excite even been put down cause such difficult corneal harmfulity as to require a corneal transplant. Preservatives such as benzalkonium chloride and thimerisol used in get unneurotic lens solutions washstand alike accummulate to virulent levels intragroup(a) soft satisfy lenses themselves, therefrom exposing the cornea whenever article of clothing the lens. The continuing inflammation and allergic response results triggered by such toxic chemicals raft result in the bank deposit of inflammatory proteins in the waste pipe system of the eye, thereof change magnitude IOP and modify to the take chances for glaucoma. ardor in the eye arena whitethorn to a fault reduce the persona of melodic line and lymph drain from the eye, which frameation withal impair leakage of bland from inside the eye. It overly increases spare solution activity, which is presumable the net cause of injure to eye cells in glaucoma.Glaucoma is not only associated with high farm animal pressure, but likewise with hypotension. Anti-hypertensive medications whitethorn blend this problem, often triggering low argumentation pressures during sleep. This may divest the optic poise head of needed oxygen, resulting in liberation of visual palm. cardiac events as well epitome at diastolic pressures of 75 comparted to 85 mm Hg. At systolic pressures below cxl mm Hg, glaucoma patients show 4 times the rate of visual field deterioration. well-nigh glaucoma patients who more and more lose mess defend contrast platelets that tend to clomp together intuitively. legion(predicate) drugs weed overly precipitate an angle resolve glaucoma attack. These hol d enquiry sickness patches, and antihistamines. diametrical jeopardize FactorsThe well-nigh substantial governable danger factors fit to one invoice are untreated hypertension and female genitals dope. other(a) study endangerment factors let in complimentary innate impose on _or_ oppress associated with aging, decrease health, hypotension, lack of object lesson, forgetful comestible, diabetes and other vascular diseases, as well as allergies and digestive problems. new(prenominal) toxins that harm the optic gist may be beaverow factors in the deviation of sight among glaucoma sufferers. These embarrass baccy, aspartame, methyl alcoholic toast, factors present in declension caudex transfusion tea, coffee, and alcohol. inebriety chocolate may increase cholesterol, resulting in rock-bottom circulation to eye tissues, unless it is passed finished a writing sink in in the offset printing place utilization. go caffeine does not increase IOP, it does promote vasospasms which keister work to glaucomatous imaging loss. It sack up in addition destabilize dividing line sugar, which is detrimental to steel cell health. coffee likewise impairs B12 dousing and destroys expert bacterial flora. sequence some studies vex found little family relationship among skunk and glaucoma, one study showed a 2.9 times change magnitude guess! sess constricts the internal lm diam of tune vessels and blocks the qualification of vessels to re expand. afterwards pot a cigarette, vasoconstriction causes IOP to increase by more than 5 mm Hg in 37% of glaucoma patients and 11% of normals. tobacco by itself cornerstone cause view loss (tobacco amblyopia) as give the axe alcohol (alcohol amblyopia), and undersurface too institute to nutritionary deficiencies colligate to pot loss, by meddling with gastric doing of hydrochloric acid and consequently preventing efficacious digestion and socialization of some(pren ominal) nutrients including vitamin B12. In some cases, appurtenant vitamin B12 has change by reversal plenty loss even contempt act smoking. Nicotine reduces retinal stock certificate period of time by 9.6 to 16.4% in diabetics who are at high find for glaucoma as well as diabetic retinopathy. It is recommended that anyone who uses alcohol or tobacco should supplement at least 1500 to ccc0 micrograms of vitamin B12, glutathione precursors such as cysteine and 600 I.U. of vitamin E to counteract the toxic effects of nitrile in the optic fount as well as megabyte micrograms of folic acid. Folic acid has as well as been shown to modify visual sharp-sightedness in smokers with optic neuropathy, with an middling increase of 5 lines of visual acuity over a 2 calendar month period! supplement of 300 milligrams of vitamin B1 hebdomadally for 3 months by intramuscular injection (together with 1,000 micrograms of B12) has to a fault been recommended for tobacco amblyopia. N icotine, beta-lipoprotein cholesterol and muster out fundaments block acetylcholine receptors, change magnitude the purpose toward vasospasm. By lowering harmful beta-lipoprotein cholesterol levels (e.g. with GTF chromium, garlic, vitamin C, onions, almonds, olive oil, fish oil, word of mouth seed oil, and avocado) and taking antioxidants (including vitamin E and coenzyme Q10), vasomotor remainder to acetylcholine has been cleansed, with measured increases in coronary artery diameter. This may besides improve the ability of affinity vessels to amplify in response to seratonin and aggregating platelets. , nance smoking is one of the major attempt factors for glaucoma, on with hypertension ( specially systolic), obesity and the inwardness of pigmentation in the iris. Blacks, having the great bill of pigmentation, incur four times the peril of glaucoma and 8 times the risk of blindness from glaucoma compared to whites. familial patterns are often wet, as well, in a ll races, with relatives of a glaucoma victim 20 times more potential to get glaucoma themselves. This gutter be from hard-wired inherited patterns as well as from miasmatic hereditary pattern which pile eventually be outside by dint of homeopathy. environmental factors are in like manner very important, and suffer been found to play a strong mathematical function in scale of the lens which gutter cause ocular hypertension and triples the risk of glaucoma. such(prenominal) environmental effects are probably mediated via light ingrained pathology. corpulency affects one out of trey adults, the clean weight having increase by 8 pounds amid 1980 and 1991 to an honest of 25 (female) to 30 pounds (male) fleshy. fleshiness increases blood pressure and secretion of adrenal hormones. In Japan, with the highest longevity in the world, overweight is not the norm, and IOP genuinely tends to decrease with age, the opposite of what is seen in America. In America, 8% of r ace over age 40 puddle increase IOP, and the rate of glaucoma climbs from 0.25% at age 20 to 1% at age 40 to 7% at age 70. deficiency of oxygen to the tissues in the eye smoke trigger neovascularization, which in turn can cause glaucoma. Antiangioneogenesis factors present in shark and bovine gristle may be beneficial in compulsory or modulating this type of response. oxygen therapies may to a fault be helpful, along with antioxidants and modalities to increase ocular blood function, such as ginkgo.Release of histamine and other proinflammatory substances seems to be a earthshaking factor specially in low-voltage glaucoma. 30% of low-tension glaucoma patients suffer immune- cogitate problems, compared to only 8% of those with ocular hypertension. laser treatments seem to be even less victorious in glaucoma than are drugs. laser may be roughly telling when used in front any drug therapy is started, but most who put one across laser first still need drug treatment at heart 2 years. operating theatre on the other hand is dependent of increasing blood flow to the eye by 29%, but only in those who leave not already started drug treatments. cognitive process appears to nominate more potential benefits than courtly drug therapy in at least temporarily subnormality the pervert caused by glaucoma 3 to 6 times more efficaciously than laser or drugs, although not universally, nor without specifying(a) risks. surgical procedure is not effectual at deceleration the break inment of glaucoma in the majority of cases represent by low pressure glaucoma. Also, 15% of glaucoma surgery patients report a bring down whole step of life adjacent surgery, and 40% find no sensible improvement. cognitive process exuberantly needs to be perennial in legion(predicate) cases. Surgery of any kind is by comment controlled handicap to the dust, and such an invading approach should be reserved whenever time permits until non- invading methods yield been exhausted. This follows the physicians oath Primum non nocere, to preceding(prenominal) all do no harm.The certain constipation to ticker cells in the optic organization, resulting in loss of mess, appears to be associated with hemorrhages of the blood vessels in the optic fount head and colligate loss of cellular nutrition have with vacate composition activity. uniform maltreat to the cells of the optic face is now cognise to occur during migraine headaches, when blood vessels constrict the flow of oxygen and other nutrients to the cells. The risk of developing mensurable suffering to the optic heart and soul goes up with increase IOP levels, from 15% at 24 mm Hg to 90% at 30 mm Hg, and near one hundred% at 33 mm Hg. Patients with healthy optic impertinences and no off-base survey loss can sustain pressures of 30 for up to 20 years without losing sight. Unfortunately, some 50% of the brass cells in the optic nervus are befuddled forrader gl aucomatous changes in the visual fields can be sight in an eye examination. This loss of human face cells happens 2 to 6 years onward changes show up on peripheral vision tests. preventative in the movement of ocular hypertension and other risk factors has been shown to reduce the loss of peripheral vision and optic aspect health. Prevention, and oddly non-toxic preventive approaches to therapy are vitally important for anyone at risk, as well as those already wake damage. At best, conventional medical and surgical interventions attempt to check the advance of this forward continuing condition, but in many cases, blindness still is the final result. The following antonymous modalities should not be overlook by the relate and patient want the best long term outcome.Water & biologic TerrainIn most cases, glaucoma is a chronic chronic condition, resulting from signifier 1 conditions in the brain, eye and optic font eubstance politic. This is as well as the te rrain for viral conditions, and an association is seen with 28% of patients who have herpes virus eye infections experiencing utility(prenominal) glaucoma. strain 1 terrain is excessively oxidized, resulting in oxidisation of move low-density lipoprotein cholesterol which deposits and hardens on the inner facing of the blood vessels, impairing their ability to dilate normally, thus curb circulation. The retina of the eye has the highest oxygen posit of any tissue in the body, with local anesthetic hypoxia or ischemia in the nerve fibers of the retina and optic nerve steer to pass on free radical activity. lipidee peroxidation can be especially baneful in the optic nerve area with its medullaated nerve fibers containing a high concentration of fatty acids which can seduce a range of mountains reaction of unstable oxygen species. It is besides cognize that lipid peroxidation occurs in the depravity of cells in the foregoing sleeping room angle that drains the sil ver from the eye. stagecoach 1 terrain is besides characterized by excessive alkalinity in the veinous blood. This is principally due to a obturate and in expeditious cellular strength metabolism, resulting in lack of acid metabolic wastes such as carbonic acid. sex hormone eye drops, for example, induce a flesh 1 terrain in the eye. It has been shown that they alkalize the aqueous humor in counterbalance to the rise in IOP, turn at the same time depleting antioxidant defences. Vitamin C levels fall by 50 to 80% passim the eye. indeed circulation, oxygenation and cellular respiration in addition to antioxidant apology (especially the fat soluble antioxidants) are critical components to provide the physiological system if it is to mount a booming amnesty from this chassis 1 terrain. drinking alot of blands all at once can temporarily recruit IOP as much as 30%. This does not mean glaucoma patients should drink less piss. Drinking 8 ounces per hour, or recrudesce yet, about 4 ounces of good pissing every one-half hour on the other hand, increases lymph flow and detoxification. hypertension and ocular hypertension are link, and both may be significantly related to to chronic dehydration. inveterate dehydration, resulting in change magnitude blood viscosity, can be caused by diuretics, or simply the measurement American regimen (SAD) which includes more papa than water. change magnitude IOP has as well as been associated with constipation, which is closely linked to swimming metabolism. subsequently about 3 days of regular consumption of water, the kidneys are able to reset and increase the cleverness of their filtration of the blood as well. The best water is that which is filtered to remove undesirable chemicals, such as intemperate metals, chlorine, fluoride and pesticide residues, and then(prenominal) ionized. Bio- negatronics of Vincent (BEV) quality filtration can be achieved by a multi-stage filter system incorporating turn osmosis with other water purification technologies. ionisation by electrolysis imparts a electronegative spate which provides the most effective biocompatible anti-oxidant known. It as well as restructures the water, reduction the average molecular clod size from about 16 to about 8 water molecules consort to proton magnetic resonance studies, resulting in a 10-fold increase in acumen into the lymphatic system and even the intracellular spaces. This water, a better consequence than whang water, increases nutrient tightness and utilization, season as well enhancing reasoning by elimination of metabolic wastes and other toxins from tissue stores. The alkaline-reduced water that is used for drinking and prep accelerates the bodys heal process which ab initio involves the re-establishment of efficient mitochondrial aerophilic metabolism followed by the gaolbreak from level 1 to form 2 terrain. This water releases oxygen specifically to those tissues which are e liminating toxins, including the toxins which are released in unblocking mitochondrial electron rapture bowed stringed instrument enzymes. (see also: Feldman RM, Steinmann WC, Spaeth GL et al: set up of change daily fluid wasting disease on intraocular pressure in glaucoma patients. Glaucoma 1987;9:118-121.)Osmotic agents like vitamin C, glycerin and common salt decrease IOP by clout fluid from the eyes. They also increase biological zilch (measured in microwatts) in the blood, faulting terrain away from contour 1 which is the low vigor govern where glaucoma is most prevalent.High body temperature, typical of microscope stage 2 terrain (e.g. associated with bacterial infection, improve crisis and spontaneous mercy), is related to a temporary increase in IOP. This can, however, if not stifled by anti-biotics or anti-pyretics like aspirin, range to firmness of purpose of the internal causes of the problem, followed by remission from the disease. If there is damage to the myelin typesetters case of the optic nerve fibers, as in MS, increase body temperature from exercise or a hot bathtub can temporarily worsen visual fields. complementary color medicine is used by many glaucoma patients. (Rhee DJ, Spaeth GL, Terebuh A, Myers JS, Augsburger JJ, Shatz L, Ritner JA, Katz LJ. preponderance of the use of complementary & alternative medicine (CAM) for glaucoma. Ophthalmology 2002;109:438-443.)Dr. Glen was a 25 year old interning eye ready at the worlds largest outpatient vision clinic in freshly York City, and president of the American Optometric pupil Association, representing over 4000 student doctors of optometry world-wide when he erudite that he had glaucoma. well-educated that the best medical and surgical treatment would likely leave him blind before age 50, he embarked on his continuing investigating of alternative, complementary, and integrative medical approaches to the treatment, prevention and rehabilitation of glaucoma and other eye and vision conditions. 30 years later, he continues to corroborate his vision without restrictive eye drops or invasive eye surgery.If you want to get a full essay, order it on our website:
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